Mihaliescu, N., Erginer Hasköylü, M. Ristoscu, C., Sennaroğlu Bostan, M., Sopronyi, M., Eroğlu, M.S., Chifiriuc, M.C., Mustaciosu, C.C., Axente, E., Toksoy Öner, E., Mihailescu, I.N., Gradient multifunctional biopolymer thin film assemblies synthesized by combinatorial MAPLE, Applied Surface Science, 466: 628-36

DOI: 10.1016/j.apsusc.2018.10.077 


Özdemir, S., Kılınç, E., Toksoy Öner, E., Preconcentrations and determinations of copper, nickel and lead in baby food samples employing Coprinus silvaticusimmobilized multi-walled carbon nanotube as solid phase sorbent, Food Chemistry, 276: 174-9

DOI: 10.1016/j.foodchem.2018.07.123



Tohme, S., Hacıosmanoğlu, G.G., Eroğlu, M.S., Kasavi, C., Genç, S., Can, Z.S., Toksoy Öner, E., Halomonas smyrnensis as a cell factory for co-production of PHB and levan, International Jourmal of Biological Macromolecules, 118 (A): 1238-46

DOI: 10.1016/J.İJBİOMAC.2018.06.197

Kırtel, O., Menéndez, C., Versluys, M., Van den Ende, W., Hernández, L., Toksoy Öner, E., Levansucrase from Halomonas smyrnensis AAD6T: First halophilic GH-J clan enzyme recombinantly expressed, purified, and characterized, Applied Microbiology and Biotechnology, 102 (21): 9207-20

DOI: 10.1007/s00253-018-9311-z


Kırtel, O. Versluys, M., Van den Ende, W., Toksoy Öner, E., Fructans of the saline world, 36 (5): 1524-39

DOI: 10.1016/j.biotechadv.2018.06.009


Erkorkmaz, B.A., Kırtel, O., Ateş Duru, Ö., Toksoy Öner, E., Development of a cost-effective production process for Halomonas levan, Bioprocess and Biosystems Engineering, 41 (9): 1247-59

DOI: 10.1007/s00449-018-1952-x


Gomes, T.D., Cardidade, S.G., Souse, M.P., Azevedo, S., Kandur, M.Y., Toksoy Öner, E., Alves, N.M., Mano, J.F., Adhesive free-standing multilayer films containing sulfated levan for biomedical applications, Acta Biomaterialia, 69: 183-195

DOI: 10.1016/j.actabio2018.01.027


Aydın, B., Özer, T., Toksoy Öner, E., Arga, K.Y., The Genome-Based Metabolic Systems Engineering to Boost Levan Production in a Halophilic Bacterial Model,  OMICS: A Journal of Integrative Biology, 22 (3): 198-209

DOI: 10.1089/omi.2017.0216


Berg, A., Toksoy Öner, E., Combie, J., Schneider, B., Ellinger, R., Weisser, J., Wyrwa, R., Schnabelrauch, M., Formation of new, cytocompatible hydrogels based on photochemically crosslinkable levan methacrylates, International Journal of Biolgoical Macromolecules, 107 (B): 2312-19

DOI: 10.1016/j.ijbiomac.2017.10.120


Özcan, E. Toksoy Öner, E., Microbial of Extracellular Polysaccharide Production from Biomass Sources, Polysaccharides: 1-21

DOI: 10.1007/978-3-319-03751-6_51-2


Avşar, G., Ağırbaşlı, D., Ağırbaşlı, M.A., Gündüz, O., Toksoy Öner, E., Levan based Fibrous Scaffolds Electrospun via Co-axial and Single-Needle Techniques for Tissue Engineering Applications, Carbohydrate Polymers, 193: 316-325

DOI: 10.1016/j.carbpol.2018.03.075


Aydoğdu, M.O., Chou, J., Altun, E., Ekren, N., Çakmak, S., Eroğlu, M., Osman, A.A., Kutlu, Ö., Toksoy Öner, E., Avşar, G., Oktar, F.N., Yılmaz, İ., Gündüz, O., Production of the biomimetic small diameter blood vessels for cardiovascular tissue engineering,  International Journal of Polymeric Materials and Polymeric Biomaterials, 1-13

DOI: 10.1080/00914037.2018.1443930

Versluys, M., Kırtel, O., Toksoy Öner, E., Van den Ende, W., The Fructan Syndrome: Evolutionary Aspects and Common Themes Among Plants and Microbes, Plant, Cell & Environment, 41 (1): 16-38




Queiroz, E.A.I.F., Fortes, Z.B., daCunha, M.A.A., Kazak Sarılmışer, H., Dekker, A.M.B., Toksoy Öner, E., Dekker, R.F.H., Khaper, N., Levan promotes antiproliferative and pro-apoptotic effects in MCF-7 breast cancer cells mediated by oxidative stress, International Journal of Biological Macromolecules, 102: 565-70

DOI: 10.1016/j.ijbiomac.2017.04.035


Sezer, A.D., Kazak Sarılmışer, H., Rayaman, E., Çevikbaş, A., Toksoy Öner, E., Akbuğa,J., Development and characterization of vancomycin-loaded levan-based microparticular system for drug delivery, Pharmaceutical Decelopment and Technology, 22(5): 627-34

DOI: 10.3109/10837450.2015.1116564


Mutlu E.C., Bostan, M.S., Bahadori, F., Toksoy Öner, E., Eroğlu, M.S., An Alternative Nano Design Strategy by Neutralized AMPS and Soy Bean Lecithin to Form Nanoparticles. World Academy of Science, Engineering and Technology, International Journal of Chemical and Molecular Engineering, 4(6)

DAI: 10.1999/1307-6892/68815


Eroğlu, M.S., Toksoy Öner, E., Mutlu, E.C., Bostan, M.S., Sugar Based Biopolymers in Nanomedicine; New Emerging Era for Cancer Imaging and Therapy,  Current Topics in Medicinal Chemistry, 17 (13), 1507-20

DOI: 10.2174/1568026616666161222101703


Osman, A., Toksoy Öner, E., Eroğlu, M.S., Novel levan and pNIPA temperature sensitive hydrogels for 5-ASA controlled release, Carbohydrate Polymers, 165, 61-70

DOI: 10.1016/j.carbpol.2017.01.097



Toksoy Öner, E., Hernández, L., Combie, J., Review of Levan polysaccharide: From a century of past experiences to future prospects, Biotechnology Advances, 34 (5), 827-44

DOI: 10.1016/j.biotechadv.2016.05.002 


Erginer, M., Akcay, A., Coskunkan, B., Morova, T., Rende, D., Bucak, S., Baysal, N., Ozisik, R., Eroglu, M. S., Agirbasli, M., Toksoy Oner, E., Sulfated levan from Halomonas smyrnensis as a bioactive, heparin-mimetic glycan for cardiac tissue engineering applications, Carbohydrate Polymers,149, 289–296



Abbamondi G.R., Suner S., Cutignano A., Grauso L., Nicolaus B., Toksoy Oner E. and Tommonaro G. Identification of N-Hexadecanoyl-L-homoserine lactone (C16-AHL) as signal molecule in halophilic bacterium Halomonas smyrnensis AAD6. Annals of Microbiology, 66 (3), 1329-33

DOI: 10.1007/s13213-016-1206-6 



Diken, E., Tugba Ozer, Muzaffer Arikan, Zeliha Emrence, Ebru Toksoy Oner, Duran Ustek and Kazim Yalcin Arga, Genomic analysis reveals the biotechnological and industrial potential of levan producing halophilic extremophile, Halomonas smyrnensis AAD6T, SpringerPlus 2015, 4:393



Kazak Sarilmiser H, Ates O, Ozdemir G, Arga KY, Toksoy Oner E. Effective stimulating factors for microbial levan production by Halomonas smyrnensis AAD6T. Journal of Bioscience and Bioengineering, 119(4), 455-63 

DOI: 10.1016/j.jbiosc.2014.09.019



Kazak Sarilmiser H, Toksoy Oner E. Investigation of anti-cancer activity of linear and aldehyde-activated levan from Halomonas smyrnensis AAD6T. Biochemical Engineering Journal, 92, 28-34

DOI: 10.1016/j.bej.2014.06.020 


Arrizon, J., Hernández-Moedano, A., Toksoy-Oner, E., González-Avila, M. (2014). In vitro prebiotic activity of fructans with different fructosyl linkage for symbiotics elaboration. International Journal of Probiotics and Prebiotics, 9(3), 69.

ISSN: 1555-1431


Axente E. Sima F, Sima L , Erginer M, Eroğlu M. S, Serban N, Ristoscu C, Petrescu S, Toksoy Oner  E, Mihailescu I. N, Combinatorial MAPLE gradient thin film assemblies signalling to human osteoblasts, Biofabrication, 28;6(3):035010

DOI: 10.1088/1758-5082/6/3/035010 


Sennaroglu Bostan M, Esra Cansever Mutlu, Hande Kazak, S. Sinan Keskin, Ebru Toksoy Oner, Mehmet S. Eroğlu, Comprehensive characterization of chitosan/PEO/levan ternary blend films, Carbohydrate Polymers, 102, 993-1000




Ateş, Ö., Arga KY, Toksoy Öner, E., The stimulatory effect of mannitol on levan biosynthesis: Lessons from metabolic systems analysis of Halomonas smyrnensis AAD6(T.) Biotechnology Progress 29(6), 1386-97

DOI: 10.1002/btpr.1823 


Costa, R. R., Neto, A. I., Calgeris, I., Correia, C. R., Pinho, A. C., Fonseca, J., E. Toksoy Oner  ve Mano, J. F. Adhesive nanostructured multilayer films using a bacterial exopolysaccharide for biomedical applications. Journal of Materials Chemistry B., 1, 2367-74

DOI: 10.1039/C3TB20137F 



Sima, F., Axente, E., Sima, L.E., Tuyel, U., Eroglu, M.S., Serban, N., Ristoscu, C., Petrescu, S.M.,  Toksoy Oner, E., Mihailescu, I.N. Combinatorial matrix-assisted pulsed laser evaporation: Single-step synthesis of biopolymer compositional gradient thin film assemblies. Applied Physics Letters, 101, 233705

DOI: 10.1063/1.4769987 


Soğutcu, E., Emrence, Z., Arikan, M., Cakiris, A., Abaci, N., Toksoy Oner, E., Ustek, D. and Arga, K.Y., Draft Genome of Halomonas smyrnensis AAD6T. Journal of Bacteriology, 194 (20), 5690-91

DOI: 10.1128/JB.00559-12 


Sima, F., Mutlu, E.C., Eroglu, M.S., Sima, L.E., Serban, N., Ristoscu, C., Petrescu, S.M., Toksoy Öner, E., Mihailescu, I.,N., Levan Nanostructured Thin Films by MAPLE Assembling, Biomacromolecules, 12, 2251–56

DOI: 10.1021/bm200340b 



Ateş, Ö., Toksoy Öner, E., Arga KY, Genome-scale Reconstruction of Metabolic Network for a Halophilic Extremophile, Chromohalobacter salexigens DSM 3043, BMC Systems Biology, 5:12

DOI: 10.1186/1752-0509-5-12 


Küçükaşık, F., Kazak, H., Güney, D., Finore, I., Poli, A., Yenigün, O., Nicolaus, B., Toksoy Öner, E. Molasses as Fermentation Substrate for Levan production by Halomonas sp. Applied Microbiology and Biotechnology, 89, 1729-40



Sezer A.D., Kazak, H., Toksoy Oner, E., Akbuğa, J. Levan-based nanocarrier system for peptide and protein drug delivery: Optimization and influence of experimental parameters on the nanoparticle characteristic. Carbohydrate Polymers, 84 (1), 358-363



Sam S., Kucukasik F., Yenigun O. ,Nicolaus B. ,Toksoy Oner E., Yukselen M. A. Flocculating Performances of Exopolysaccharides Produced by a Halophilic Bacterial Strain Cultivated on Agro-industrial Waste, Bioresource Technology, 102 (2), 1788-94




Poli, A., Kazak, H., Gürleyendağ, B., Tommonaro, G., Pieretti, G., Toksoy Öner, E., Nicolaus, B.,High level synthesis of levan by a novel Halomonas species growing on defined media, Carbohydrate Polymers, 78, 651-657




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